Milk spiked with casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) has a positive remineralization effect on enamel subsurface lesions in situ, according to a study in the Australian Dental Journal (September 2009, Vol. 54:3, pp. 245-249).
In a double-blind, three-way crossover randomized study, conducted at the University of Melbourne's Cooperative Research Centre for Oral Health Science, 10 subjects drank 100 mL of bovine milk containing no added CPP-ACP (control), 0.2% CPP-ACP, or 0.3% CPP-ACP for 30 seconds a day for 15 days while wearing removable appliances with attached slabs of enamel containing subsurface enamel lesions.
After each treatment and a one-week "washout" period, the subjects crossed over to another treatment; this process was repeated until they had consumed each of the three milk products. At the completion of each treatment, the enamel slabs were removed and remineralization determined using microradiography.
While all three milk samples remineralized enamel subsurface lesions in situ, the two milk samples containing added CPP-ACP each produced significantly greater remineralization than the control milk, the researchers found. The milk containing 0.2% CPP-ACP produced an 81% increase in mineral content relative to the control milk, while the milk containing 0.3% CPP-ACP produced a 164% increase in mineral content.
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